Discovery of a tRNA-like base sequence in the coronavirus genome and possible mechanism of actionArticle Published on 2022-11-012022-11-16 Journal: Genes & genomics [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome base Base sequence Cloverleaf model of tRNA complementary coronavirus Evidence function genetic component Genome homology human gene intron involved mechanism of action Messenger RNA molecular Mutation mutation. produced question robust SARS-CoV SARS-CoV-2 sequence therapeutic agents viruses [DOI] 10.1007/s13258-022-01299-w PMC 바로가기
Insertion/deletion hotspots in the Nsp2, Nsp3, S1, and ORF8 genes of SARS-related coronavirusesArticle Published on 2022-10-282022-11-16 Journal: BMC Ecology and Evolution [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome animal hosts base bases bat bat coronavirus benefit Characteristics classical complex coronavirus determine Frame Future Genome genomic region hotspot Human human SARS-CoV-2 human SARS-CoV-2 strain INDEL Indel hotspot indels insertion/deletion insertion/deletion (indel). mechanism Multiple sequence alignment Mutation N-terminal domain Neutral non-structural protein Occurrence offer ORF8 ORF8 gene pangolin Pangolin coronavirus (PCoV) Point mutation RaTG13 Region reported RNA sequence S1 domain SARS-CoV SARS-CoV-2 SARS-related coronavirus SARS-related coronaviruses severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) survival the spike protein viral evolution virus virus viruses [DOI] 10.1186/s12862-022-02078-7 PMC 바로가기
Human genetic basis of severe or critical illness in COVID-19Article Published on 2022-09-202022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome affecting association Asymptomatic base caused contribute coronavirus COVID-19 Critical Critical illness death determinant disease disease severity enhanced Enzymes Factor Genetic Genetic variation genetic. Host Human human leukocyte antigen immune component indicated Interaction Interleukins loci mild infection morbidity and mortality multi-organ dysfunction outcome Precision preventive measure Respiratory failure SARS-CoV-2 SARS-CoV-2 receptor Serine severity of COVID-19 Toll-like receptor transmembrane [DOI] 10.3389/fcimb.2022.963239 PMC 바로가기
Extended Delay to Treatment for Stage III-IV Non–Small-Cell Lung Cancer and Survival: Balancing Risks During the COVID-19 PandemicResearch article Published on 2022-09-012022-10-05 Journal: Clinical lung cancer [Category] 치료법, [키워드] all-cause mortality Analysis association balancing base can be used Care Cell Cohort coronavirus disease COVID-19 COVID-19 pandemic Cox regression analysis cumulative decrease Delay Diagnosis Extended hazard ratio lung adenocarcinoma lung cancer material National no significant difference outcomes pandemic Patient patient survival Result Screening sensitivity analysis significantly spline Stage survival Treatment was performed was used [DOI] 10.1016/j.cllc.2022.05.001 [Article Type] Research article
Current management of infantile cataractsReview article Published on 2022-09-012022-10-05 Journal: Survey of Ophthalmology [Category] 비임상, [키워드] absence approach association base benefit Better Cataract Cataracts cause children Complication Contact country current demonstrated description effort Epidemiological study etiology Evolution eyes Guidance healthy highlight IMPROVE infancy Infant Infantile cataract less management Molecular genetics morphology nystagmus outcome outcomes patients performed Prevalence Prognostic value recent Research surgical therapy treatable visual impairment while [DOI] 10.1016/j.survophthal.2022.03.005 [Article Type] Review article
Structural bases for the higher adherence to ACE2 conferred by the SARS-CoV-2 spike Q498Y substitutionArticle Published on 2022-09-012022-11-16 Journal: Acta crystallographica. Section D [Category] SARS, 변종, [키워드] ACE2 ACE2 receptor addition amino-acid analysis base binding binding affinity binding kinetics circulating SARS-CoV-2 variant circulating SARS-CoV-2 variants complex Contact contribute COVID-19 host-pathogen interactions in vitro in vivo model increase increase in Infection Interaction Lineage mice modulate mutant Mutation performed Q498Y RBD RBD-ACE2 RBD–ACE2 complex receptor ACE2 Receptor binding domain reveal SARS-CoV-2 SARS-CoV-2 variant shown Spike protein spike protein Q498Y mutation spike protein receptor binding domain. spike receptor-binding domain Substitution the binding affinity the RBD the SARS-CoV-2 the spike protein while wild-type counterpart X-ray X-ray structure [DOI] 10.1107/S2059798322007677 PMC 바로가기
Persistence, prevalence, and polymorphism of sequelae after COVID-19 in unvaccinated, young adults of the Swiss Armed Forces: a longitudinal, cohort study (LoCoMo)Research article Published on 2022-08-262022-10-05 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 진단, [키워드] Administered Adults aerobic age asymptomatic infection base Blood BMI cardiovascular complications cholesterol cohort study Concentration control group COVID-19 COVID-19 group criteria defined Diagnosis diagnostic dyslipidaemia enrolled fatigue Fatigue scale female finding Follow-up force funding Health healthy higher risk individual Intensive IQR Laboratory Laboratory parameters LDL longitudinal cohort study male management median men metabolic disorder negative RT-PCR neurological no symptoms non-hospitalised organ systems outcomes participant Participants persistent physical polymorphism positive positive PCR test presenting Prevalence Psychological public health quantified questionnaire Registered renal reported reproductive RT-PCR test SARS-CoV-2 SARS-COV-2 infection Serologically serologically positive significant difference study groups Switzerland Symptom the median threshold were excluded with COVID-19 [DOI] 10.1016/S1473-3099(22)00449-2 [Article Type] Research article
Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activityResearch article Published on 2022-08-242022-10-05 Journal: Molecular Therapy. Nucleic Acids [Category] 치료제, [키워드] acute respiratory syndrome antiviral activity antiviral response antiviral therapeutic antiviral therapeutics base base pairs blunt cell lines Characteristics coronavirus coronavirus disease COVID-19 described DNA double-stranded RNA dsRNAs groups highlight Hoogsteen G-G base pairing human lung IFN IFN-I IFN-III immunostimulant immunostimulatory immunostimulatory RNA independent induce Infection Influenza influenza A virus interferon lack lung MERS-CoV Middle East monophosphate motif MT: Oligonucleotides not affect organ on a chip pandemic pathophysiology pathway proinflammatory receptor respiratory syndrome coronavirus respiratory virus RIG-I RNA RNAs SARS-CoV SARS-CoV-2 SARS-COV-2 infection sequence siRNAs terminal hydroxyl Therapies and Applications TLR type I type III interferon unique [DOI] 10.1016/j.omtn.2022.08.031 [Article Type] Research article
Fast Prediction of Binding Affinities of SARS-CoV-2 Spike Protein and Its Mutants with Antibodies through Intermolecular Interaction Modeling-Based Machine Learning분자간 상호작용 모델링 기반 기계 학습을 통한 SARS-CoV-2 스파이크 단백질 및 항체와의 돌연변이체의 결합 친화도의 빠른 예측Article Published on 2022-07-212022-09-11 Journal: The journal of physical chemistry. B [Category] COVID19(2023년), SARS, 변종, [키워드] addition affinity antibodies antibodies binding antibody resistance Antibody therapeutics antigens approach artificial intelligence base binding binding affinities binding affinity COVID-19 Cryo-electron microscopy develop Effect help Interaction intermolecular interaction intermolecular interactions machine learning machine learning model machine learning models methodology modeling monoclonal antibodies monoclonal antibody mutant Mutation novel SARS-CoV-2 virus overcome pandemic predict prediction produced Receptor binding domain reported SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody SARS-CoV-2 virus spike Spike protein Structure the binding affinity the spike protein the vaccine variant variants of concern was used wild-type wild-type virus X-ray crystallography [DOI] 10.1021/acs.jpcb.2c02123 PMC 바로가기 [Article Type] Article
Genomic surveillance of SARS-CoV-2 in US military compounds in Afghanistan reveals multiple introductions and outbreaks of Alpha and Delta variants아프가니스탄의 미군 화합물에서 SARS-CoV-2의 게놈 감시는 알파 및 델타 변이체의 다중 도입 및 발생을 보여줍니다Article Published on 2022-07-152022-09-11 Journal: BMC Genomics [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] Afghanistan alpha and delta variants analyzed base collected Compound compounds Delta delta variant Epidemiology genomic Genomic surveillance independent military occur occurred outbreak Outbreaks phylogenetic analyses phylogenetic analysis reveal SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2. Sequencing Spread Surveillance sustained variant variants virus [DOI] 10.1186/s12864-022-08757-5 PMC 바로가기 [Article Type] Article